Structures of LRP2 reveal a molecular machine for endocytosis

Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L.

Cell. 2023 Feb 16;186(4):821-836.e13.

Structure and functional determinants of Rad6-Bre1 subunits in the histone H2B ubiquitin-conjugating complex

Shukla PK, Bissell JE, Kumar S, Pokhrel S, Palani S, Radmall KS, Obidi O, Parnell TJ, Brasch J, Shrieve DC, Chandrasekharan MB.

Nucleic Acids Res. 2023 Jan 30:gkad012. Online ahead of print.

Computational model of E-cadherin clustering under force

Chen Y, Brasch J, Harrison OJ, Bidone TC.
Biophys J. 2021 Nov 16;120(22):4944-4954.

Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins

Harrison OJ*, Brasch J*, Katsamba PS, Ahlsen G, Noble AJ, Dan H, Sampogna RV, Potter CS, Carragher B, Honig B, Shapiro L.
Cell Rep. 2020 Feb 25;30(8):2655-2671.e7.

Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs

Bepler T, Morin A, Rapp M, Brasch J, Shapiro L, Noble AJ, Berger B.
Nat Methods. 2019 Nov;16(11):1153-1160.

Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope

Evangelista F, Roth AJ, Prisayanh P, Temple BR, Li N, Qian Y, Culton DA, Liu Z, Harrison OJ, Brasch J, Honig B, Shapiro L, Diaz LA.

J Autoimmun. 2018 May;89:171-185.

Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins

Larsen ISB, Narimatsu Y, Joshi HJ, Siukstaite L, Harrison OJ, Brasch J, Goodman KM, Hansen L, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11163-11168.

Visualization of clustered protocadherin neuronal self-recognition complexes

Brasch J*, Goodman KM*, Noble AJ, Rapp M, Mannepalli S, Bahna F, Dandey VP, Bepler T, Berger B, Maniatis T, Potter CS, Carragher B, Honig B, Shapiro L.
Nature. 2019 May;569(7755):280-283.

Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites

Zeiske T, Baburajendran N, Kaczynska A, Brasch J, Palmer AG 3rd, Shapiro L, Honig B, Mann RS.

Cell Rep. 2018 Aug 28;24(9):2221-2230.

 Routine single particle CryoEM sample and grid characterization by tomography

Noble AJ, Dandey VP, Wei H, Brasch J, Chase J, Acharya P, Tan YZ, Zhang Z, Kim LY, Scapin G, Rapp M, Eng ET, Rice WJ, Cheng A, Negro CJ, Shapiro L, Kwong PD, Jeruzalmi D, des Georges A, Potter CS, Carragher B.

Elife. 2018 May 29;7:e34257.

Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior

Brasch J, Katsamba PS, Harrison OJ, Ahlsén G, Troyanovsky RB, Indra I, Kaczynska A, Kaeser B, Troyanovsky S, Honig B, Shapiro L.
Cell Rep. 2018 May 8;23(6):1840-1852.

Structural basis of adhesive binding by desmocollins and desmogleins

Harrison OJ*, Brasch J*, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L.
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7160-5. doi: 10.1073/pnas.1606272113. Epub 2016 Jun 13. PMID: 27298358; PMCID: PMC4932976